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OS-01 Peptide™
| Category | Key claim | Clinical details |
|---|---|---|
| Biological Age | The OS-01 Peptide™ reverses skin's biological age. | Based on ex vivo lab studies measuring epigenetic markers and using a skin-specific molecular clock which indicate skin's biological age ( Zonari et al., npj Aging, 2023; Boroni et al., Clinical Epigenetics, 2020). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Cellular Senescence | The OS-01 Peptide™ reduces senescence in skin. The OS-01 Peptide™ reduces SASP-secreting cells, slowing the spread and accumulation of senescence in skin. |
Based on ex vivo and in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Repair | The OS-01 Peptide™ supports skin's natural repair processes. | Based on in vitro lab studies measuring cellular damage biomarker, γH2A.x, and evaluating PP2A, involved in cellular repair, which indicate repair processes ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| UV-induced senescence / UV aging | The OS-01 Peptide™ reduces/prevents UV-induced senescence / UV aging in skin by 42.5%. | Based on in vitro lab studies measuring levels of senescence before and after UVB exposure which indicate UV-induced senescence and aging ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| UV-induced inflammation | The OS-01 Peptide™ reduces/prevents UV-induced inflammation biomarkers in skin. | Based on in vitro lab studies measuring inflammation biomarkers (IL-6 and CCL2) before and after UVB exposure which indicate UV-induced inflammation ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Dark Spots | The OS-01 Peptide™ targets the appearance of dark spots at the cellular level. | Based on in vitro lab studies measuring melanin which indicate the appearance of dark spots ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Inflammation | The OS-01 Peptide™ reduces a key inflammation biomarker in skin. | Based on ex vivo lab studies measuring inflammation biomarker (IL-6) which indicate inflammation ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Hyaluronic Acid | The OS-01 Peptide™ increases a key hyaluronic acid production biomarker in skin by 246% / promotes hyaluronic acid production in skin by 246%. | Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Collagen | The OS-01 Peptide™ increases a key collagen production biomarker in skin by 179% / promotes collagen production in skin by 179%. | Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Keratin | The OS-01 Peptide™ increases key keratin production biomarkers in skin / promotes keratin production in skin. | Based on ex vivo lab studies measuring keratin production biomarkers (KRT1 and KRT14) which indicate keratin production ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Senescence in hair | The OS-01 Peptide™ targets senescence in hair. The OS-01 Peptide™ significantly reduces a key senescence biomarker in stressed hair cells. |
Based on in vitro lab studies measuring senescence biomarker (CDKN1A/P21) which indicate senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 Peptide™
OS-01 FACE MOISTURIZER
| Category | Key claim | Clinical details |
|---|---|---|
| Aging/senescence | OS-01 FACE MOISTURIZER reduces key aging/senescence biomarkers in skin. | Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A and B2M) which indicate senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Collagen | OS-01 FACE MOISTURIZER increases a key collagen production biomarker in skin y 51% / promotes collagen production in skin by +51%. | Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| OS-01 FACE MOISTURIZER vs Retinol – Collagen | OS-01 FACE MOISTURIZER and retinol both increase a key collagen production biomarker in skin / promote collagen production in skin in the acute phase of treatment. | Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicates collagen production ( Zonari, A., et al. npj Aging, 2023). These results represent acute responses to the products after 5 days of exposure, and may not reflect long-term results. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| OS-01 FACE MOISTURIZER vs Retinol – Aging/Senescence | Retinol increases a key aging/senescence biomarker more than 10-fold in the epidermis versus untreated skin, while OS-01 FACE MOISTURIZER significantly reduces it, in the acute phase of treatment. | Based on ex vivo lab studies measuring senescence biomarker (CDKN2A) which indicates senescence ( Zonari, A., et al. npj Aging, 2023). These results represent acute responses to the products after 5 days of exposure, and may not reflect long-term results. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 FACE MOISTURIZER
OS-01 EYE CREAM
| Category | Key claim | Clinical details |
|---|---|---|
| Collagen Degradation | OS-01 EYE CREAM reduces a key collagen degradation biomarker in skin / helps reduce collagen breakdown in skin. | Based on ex vivo lab studies measuring collagen degradation biomarker (MMP1) which indicate collagen degradation ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Collagen | OS-01 EYE CREAM increases collagen by 2.3x (+130%). | Based on ex vivo lab studies measuring collagen ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Aging/senescence | OS-01 EYE CREAM reduces a key cellular senescence and aging biomarker in skin. | Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A) which indicate senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Inflammation | OS-01 EYE CREAM reduces a key inflammation biomarker in skin. | Based on ex vivo lab studies measuring inflammation biomarker (IL-8) which indicates inflammation ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 EYE CREAM
OS-01 HAIR SCALP SERUM
| Category | Key claim | Clinical details |
|---|---|---|
| Age-related thinning | OS-01 HAIR SCALP SERUM targets a root cause of age-related hair thinning – cellular senescence. | Based on ex vivo and in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Stress-related hair thinning | OS-01 HAIR SCALP SERUM reduces CRH-induced senescence. CRH is a stress hormone, therefore this data suggests that OS-01 HAIR SCALP SERUM may be a potential candidate for addressing stress-induced hair thinning. | Based on in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Pattern thinning | OS-01 HAIR SCALP SERUM targets a potentially exacerbating factor of pattern thinning – cellular senescence. | Based on in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence ( Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Inflammation biomarkers | OS-01 HAIR SCALP SERUM significantly reduces a key inflammation biomarker. | Based on in vitro lab studies measuring inflammation biomarker (IL-6) which indicate inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 HAIR SCALP SERUM
OS-01 LIP MASK
| Category | Key claim | Clinical details |
|---|---|---|
| Collagen | OS-01 LIP MASK increases key collagen production biomarker in skin by +138% / promotes collagen production in skin by +138%. | Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Collagen (vs luxury lip mask) | OS-01 LIP MASK increases key collagen production biomarker (COL1A1) in skin by +101% more than a luxury award-winning lip mask / promotes collagen production in skin by +101% more than a luxury award-winning lip mask. | Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Elastin | OS-01 LIP MASK increases key elastin production biomarker in skin by +133% / promotes elastin production in skin by +133%. | Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Elastin (comparative) | OS-01 LIP MASK increases key elastin production biomarker in skin / promotes elastin production in skin more than comparative products: +135% vs. leading drugstore lip product; +101% vs. market leading peptide lip treatment; +67% vs. luxury award-winning lip mask. |
Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Hyaluronic Acid | OS-01 LIP MASK increases key hyaluronic acid production biomarker (HAS2) in skin by +51% / promotes hyaluronic acid production in skin by +51%. | Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Hyaluronic Acid (vs drugstore) | OS-01 LIP MASK increases key hyaluronic acid production biomarker (HAS2) in skin by +41% / promotes hyaluronic acid production in skin by +41% more than a leading drugstore lip product. | Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Senescence/aging | OS-01 LIP MASK decreases key senescence/aging biomarker compared to leading competitors: −17% vs. market leading peptide lip treatment; −17% vs. leading drugstore lip product. |
Based on ex vivo lab studies measuring levels of senescence biomarker (CDKN1A/P21) which indicates senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 LIP MASK
OS-01 LIP SPF
| Category | Key claim | Clinical details |
|---|---|---|
| Effects of UV-induced stress | OS-01 LIP SPF (untinted) protects skin from the effects of UV-induced stress by reducing inflammation, degradation, and senescence/aging biomarkers in skin: UV-induced inflammation biomarker by 103% UV-induced degradation biomarker by 87% UV-induced senescence/aging biomarker by 104% |
Based on ex vivo lab studies measuring levels of inflammation, degradation, and senescence/aging biomarkers (IL-8, MMP3, and CDKN1A/P21) before and after UVB exposure which indicate UV-induced skin stress. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Senescence/aging | OS-01 LIP SPF (untinted) reduces existing senescence and aging biomarkers: CDKN1A/P21 by −20% CDKN2A/P16 by −21% |
Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A/P16 and CDKN1A/P21) which indicate reduction in existing senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Elastin | OS-01 LIP SPF (untinted) increases key elastin production biomarker by +47% / promotes elastin production in skin by +47%. | Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 LIP SPF
OS-01 FACE SPF
| Category | Key claim | Clinical details |
|---|---|---|
| UV-induced senescence | OS-01 FACE SPF protects against UV-induced senescence, superior to regular sunscreen. | Based on ex vivo lab studies measuring levels of senescence biomarker (P16 / CDKN2A) before and after UVB exposure which indicate UV-induced senescence and aging. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Senescence/aging | OS-01 FACE SPF reduces existing senescence/aging biomarkers in skin. OS-01 FACE SPF reduces effects of past aging in skin. |
Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A/P16) which indicates reduction in senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Inflammation biomarker | OS-01 FACE SPF reduces a key inflammation biomarker in skin. | Based on ex vivo lab studies measuring inflammation biomarker (IL-6) which indicate inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Antioxidant power | OS-01 FACE SPF scavenges free radicals 4x more effectively than a leading anti-aging antioxidant SPF moisturizer. | Based on lab studies measuring free radical scavenging which indicates antioxidant power. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Antioxidant power (vs vitamin C) | OS-01 FACE SPF performs similarly to common vitamin C serums at neutralizing free radicals. | Based on lab studies measuring free radical scavenging which indicates antioxidant power. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 FACE SPF
OS-01 BODY SPF
| Category | Key claim | Clinical details |
|---|---|---|
| Collagen | OS-01 BODY SPF protects skin from UV-induced collagen degradation. | Based on ex vivo lab studies measuring levels of collagen before and after UVB exposure. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| UV-induced senescence/aging | OS-01 BODY SPF reduces UV-induced senescence / UV aging in skin. | Based on ex vivo lab studies measuring levels of senescence biomarker (P16) before and after UVB exposure which indicate UV-induced senescence and aging. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| UV-induced inflammation biomarker | OS-01 BODY SPF reduces a UV-induced inflammation biomarker in skin. | Based on ex vivo lab studies measuring levels of inflammation biomarker (IL-8) before and after UVB exposure which indicate UV-induced inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| UV-induced hyaluronic acid degradation | OS-01 BODY SPF reduces a UV-induced hyaluronic acid degradation biomarker in skin. | Based on ex vivo lab studies measuring levels of hyaluronic acid degradation biomarker (HYAL1) before and after UVB exposure which indicate UV-induced hyaluronic acid degradation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
OS-01 BODY SPF
FACE CLEANSER (PREP)
| Category | Key claim | Clinical details |
|---|---|---|
| Peptide Absorption | FACE CLEANSER can improve OS-01 peptide absorption by 2.2x. | Based on ex vivo lab studies measuring peptide levels in skin which indicate absorption. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
| Hydration | Compared to using OS-01 FACE MOISTURIZER alone, FACE CLEANSER can significantly increase a key hydration biomarker (AQP3) when used prior to OS-01 FACE MOISTURIZER. | Based on ex vivo lab studies measuring hydration biomarker (AQP3) which indicate hydration. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims. |
FACE CLEANSER (PREP)
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FrontrowMD and the clinicians
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Who is FrontrowMD?
FrontrowMD is an independent, third-party platform on a mission to make it easier to discover health products you can trust.
Here’s how: first, we make it easy for clinicians to share discounts on their own selection of health products to help their patients. We often hear that our clinician partners are worried about patients spending their hard-earned money on products that may not be best for them.
Then, we digitally track which products our clinicians include on their patient discount pages and display that data to you, verifying that medical experts are choosing to share this product and making it easier to discover the right product for you.
Who / how many clinicians share this?
Clinicians sharing this product include doctors, nurse practitioners, and physician associates. Right now, 262 clinicians are including this product on their personalized patient discounts page, out of hundreds of product options.
Group practices often request to collaborate on one page instead of setting up separate free pages (this way, it’s easier for patients at a medical practice to shop through a single page).
Below, you can see the names of clinicians or practices sharing this product, including how many clinicians chose to collaborate at that practice to sum up the total number of clinicians sharing this product.
What does “share” mean?
Clinicians have the choice to add / remove any health product (either individually, or often in bulk) to their patient discounts pages whenever they would like.
Therefore, FrontrowMD defines a product as being “shared” if that specific product is included in their personalized page and if those clinicians indicated on their “Getting Started” form that they intend to make their page available to patients (like through leaving out ‘Savings Cards’ with QR codes that link to the page), regardless of the number of products they keep / remove, how thoroughly they review each product, and the number of patients who choose to visit these pages.
This is different than a clinician recommending or “prescribing” this product to an individual patient, which clinicians are often less comfortable doing because of liability concerns — clinicians instead often appreciate being able to choose to share a product on their page that is broadly available to all patients.
When you click on 'Preview' below, you’ll be taken to a filtered view of those clinicians’ personalized pages, so you can confirm they included this product. While there, you can even download the “Getting Started” form they submitted by clicking ‘Confirm’ in the full list of clinicians. Only patients of these clinicians can shop on that page.
Are clinicians paid to do this?
No — clinicians are never compensated. This is a free platform for clinicians and patients. These clinicians include products on their personalized discounts pages, which you can preview below, to benefit their patients.
Clinicians who shared this product
For the complete list, click here. Numbers below indicate how many clinicians collaborate to share products on a single page at a medical practice.
5 Elevate Dermatology and Plastic Surgery
Henrico, VA • 5 Providers
1 Dr. Ivana Amajoh Anunobi
Missouri City, TX
1 Dr. Sarah Yamaguchi
1127 Wilshire Blvd, Ste 1202 Los Angeles, CA 90017
1 Dr. Lisa Castellano Howard
Tampa, FL
1 Dr. Leah Cohen
Sarasota, FL
1 Dr. Sanam Campbell
Blacksburg, VA
1 Dr. Megan Barry
Charlottesville, VA
1 Dr. Melissa Dixon
Neptune, New Jersey
1 Dr. Manhong Ma, MD
Toms River, NJ
1 Dr. Laura Bonaker
Elmer, New Jersey
See the full list of clinicians and learn more
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